Welcome to the Conine Lab 

At the University of Pennsylvania and Children's Hospital of Philadelphia

The functions of small RNAs in fertility, inheritance, and development

The lab investigates how RNAs present in sperm are capable of transmitting non-genetic information to their progeny, influencing offspring phenotype, including: 

1) How small RNAs regulate gene expression in the male germline to support spermatogenesis and fertility

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2) How small RNAs are packaged into mature sperm

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3) How RNAs transmitted during fertilization are able to regulate early embryonic gene expression and development

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4) How this regulation can alter developmental programs to produce a non-genetically inherited phenotype

The lab utilizes a combination of state-of-the-art genomic, molecular biology, and assisted reproduction techniques across multiple model systems including mice, embryonic stem cells, and C. elegans to understand these questions.