The Functions of Small RNAs in Fertility, Inheritance, & Development
The Conine Lab investigates how RNAs present in sperm are capable of transmitting non-genetic information to their progeny, and influencing offspring phenotype. We utilizes a combination of state-of-the-art genomics, molecular biology, and assisted reproduction techniques across multiple model systems including mice, embryonic stem cells, and C. elegans to understand these questions:
How small RNAs regulate gene expression in the male germline to support spermatogenesis and fertility?
How small RNAs are packaged into mature sperm?
How RNAs transmitted during fertilization are able to regulate early embryonic gene expression and development?
How this regulation can alter developmental programs to produce a non-genetically inherited phenotype?